Q- A 30-year-old man presents to the office for progressive pain with urination for 1 year. He also complains of episodes of blood in urine in different occasions. He lived in Egypt until he came to the states 6 months ago. Physical examination reveals suprapubic tenderness. Imaging shows bilateral hydroureter and hydronephrosis and calcification in the region of the bladder. A biopsy of the bladder shows chronic inflammation with fibrosis and granulomas.
Which of the following is the most likely diagnosis?
A- Chronic pyelonephritis
B- Interstitial cystitis
D- Systemic lupus erythematosus
Q- 1 in 13 African American babies is born with sickle cell trait. Which of the following is the chance that a newly married African American couple to have a child affected by sickle cell disease?
Q- Which of the following is the enzymatic defect in cases of xeroderma pigmentosa?
A- DNA polymerase
B- DNA ligase
C- Excision repair enzymes
D- RNA polymerase III