Q- Which one of the following is an estimate for the fraction of administered drug that reaches systemic circulation unchanged?
A- Bioavailability
B- Clearance
C- Half-life
D- Volume of distribution
A- Bioavailability- for IV dose, bioavailability is 100% while for oral dose it is less than 100%. Clearance is the amount of plasma cleared of drug per unit time. Half-life is the time required to change to half of the amount of the dose. Volume of distribution is the volume occupied by total drug in the body in a relation to its plasma concentration.
Q- Which one of the following drugs may cause pancreatitis as an adverse effect?
A- Acetaminophen
B- Didanosine
C- Clindamycin
D- Rifampin
B- Didanosine- It is a reverse transcriptase inhibitor. It may cause pancreatitis. Other drugs that can cause pancreatitis are corticosteroids, alcohol, valproic acid, and azathioprine.
Q- Which one of the following antibiotics can cause interstitial nephritis?
A- Amoxicillin
B- Oxacillin
C- Piperacillin
D- Ticarcillin
B- Oxacillin- It also can cause hypersensitivity reactions. Other drugs that can cause interstitial nephritis are nafcillin and dicloxacillin and they all are penicillinase-resistant penicillins.
Thank you so much Dr. Mohamednor. I appreciate your feedback.
Dr Ray thank you again for your helping us