Repeated USMLE Questions Step 1- Review- 81- Pharmacology

Q- Which one of the following is an estimate for the fraction of administered drug that reaches systemic circulation unchanged?

A- Bioavailability

B- Clearance

C- Half-life

D- Volume of distribution

A- Bioavailability- for IV dose, bioavailability is 100% while for oral dose it is less than 100%. Clearance is the amount of plasma cleared of drug per unit time. Half-life is the time required to change to half of the amount of the dose. Volume of distribution is the volume occupied by total drug in the body in a relation to its plasma concentration.

Q- Which one of the following drugs may cause pancreatitis as an adverse effect?

A- Acetaminophen

B- Didanosine

C- Clindamycin

D- Rifampin

B- Didanosine- It is a reverse transcriptase inhibitor. It may cause pancreatitis. Other drugs that can cause pancreatitis are corticosteroids, alcohol, valproic acid, and azathioprine.

Q- Which one of the following antibiotics can cause interstitial nephritis?

A- Amoxicillin

B- Oxacillin

C- Piperacillin

D- Ticarcillin

B- Oxacillin- It also can cause hypersensitivity reactions. Other drugs that can cause interstitial nephritis are nafcillin and dicloxacillin and they all are penicillinase-resistant penicillins.

More Pharmacology MCQs

Check this Review Book for USMLE Step 1

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