Repeated USMLE Questions Step 1- 303

A 1-year-old girl is brought to the pediatrician by her parents due to poor growth and skeletal abnormalities. Laboratory investigations show microcytic anemia and higher concentration of hemoglobin A2. Which is the most likely diagnosis? A- Sickle cell anemia B- β-thalassemia C- Lead poisoning D- Iron deficiency Answer β-thalassemia is an inherited blood disorder that … Read more

Repeated USMLE Questions Step 1- 298

A 56-year-old man presents to the clinic due to recurrent attacks of severe pain in his right big toe for the last few weeks. During the attacks, his toe becomes painful, red, warm and swollen. Significant improvement occurs after treatment with colchicine. Synovial fluid analysis is performed to confirm the diagnosis. What is the most … Read more

Repeated USMLE Questions Step 1- 297

A 4-year-old boy visits you in the clinic with his mother for evaluation of an increasing size of his genitalia. She tells you that her boy had aggressive behavior for the last six months. Besides progressive increase of the length of his penis, he has excessive pubic hair. On examination, his pulse is 80/min. and … Read more

Repeated USMLE Questions Step 1- 296

A 21-year-old pregnant woman visits her physician for a prenatal visit. Ultrasonography shows neural tube defects. The patient was not compliant with her medications. Assuming that the condition is caused by deficiency of a certain nutrient, which one of these abnormalities would be seen as well? A-Coagulation disorder B-Microcytic anemia C-Macrocytic anemia D-Macrocytic anemia with … Read more

Repeated USMLE Questions Step 1- 295

A 40-year-old woman complains of fatigue, headache and generalized pain for 9 months. She presented to the clinic several times and had multiple negative workups. Her pain started as localized to her head, neck and shoulder but now it is generalized. On physical examination, there are multiple points of tenderness on bony prominences. What is … Read more

Repeated USMLE Questions Step 1- 293

A 14-year-old student is brought to the emergency room complaining of severe abdominal pain. Diagnostic tests reveal high serum levels of δ-aminolevulinate and porphobilinogen and low level of uroporphyrinogen I synthetase in urine. Given the above test results, which of the following symptoms would be presented in this case? A- Hypotension B- Polyphagia C- Neuropsychiatric … Read more