Q- A 65-year-old man presents to the clinic complaining of weakness and recurrent infections for 6 months. He has no significant medical, surgical or family history. Physical examination reveals multiple enlarged lymph nodes. Histopathology reveals excessive mature B cells that mark strongly with CD5 and CD23 and weekly with CD22. They also have weak expression of kappa chains on the plasma membrane.
Which of the following is the most likely diagnosis?
A- Acute lymphatic leukemia
B- Chronic lymphocytic leukemia
C- Chronic myeloid leukemia
D- Hairy cell leukemia
E- Sezary syndrome
Answer
Chronic lymphocytic leukemia usually affects older adults, like this 65-year-old man. His symptoms are weakness, infections, and swollen lymph nodes are common in CLL. CD5 and CD23 positive are key markers for CLL. Weak expression of kappa chains and CD22, also typical for CLL.
The correct answer is B
B