Repeated USMLE Questions Step 1- Review- 152

Q- A 65-year-old man with heart failure is started on spironolactone. Which adverse effect should be monitored most closely?

A- Gynecomastia

B- Hypocalcemia

C- Hypokalemia

D- Metabolic acidosis

A- Gynecomastia- Spironolactone is an aldosterone antagonist with antiandrogen effects that can cause gynecomastia and hyperkalemia.

 

Q- A 60-year-old man presents with weakness, fatigue, and splenomegaly. His complete blood count shows pancytopenia. Bone marrow aspiration is “dry,” but biopsy shows fibrotic marrow with atypical megakaryocytes.
What is the most likely diagnosis?

A- Acute lymphoblastic leukemia

B- Aplastic anemia

C- Chronic myeloid leukemia

D- Myelofibrosis

D- Myelofibrosis- Myelofibrosis features bone marrow fibrosis leading to extramedullary hematopoiesis, splenomegaly, and “dry tap” on aspiration.

 

Q- A patient receiving chemotherapy develops severe nausea and vomiting. Which drug works by blocking serotonin (5-HT₃) receptors to control these symptoms?

A- Metoclopramide

B- Ondansetron

C- Promethazine

D- Scopolamine

B- Ondansetron- Ondansetron is a 5-HT₃ receptor antagonist commonly used for chemotherapy-induced nausea and vomiting.

 

Read this Review Book for Step 1 

More Repeated USMLE Questions Step 1

author avatar
Dr Ray Makar

Leave a Comment