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Pharmacology MCQs- 229

Studies are done on normal volunteers for phase 1 clinical trials of a new drug. The volume of distribution and clearance has been measured. The researchers now are calculating the half-life of the drug.

Assuming that the volume of distribution is 60 L and the clearance is 3 L/hour, what is the approximate half-life of this drug?

A- 1/2 an hour

B- 6 hours

C- 12 hours

D- 14 hours

E- 18 hours

Answer



To calculate the half-life of a drug, we need to memorize this equation:

t(½) = 0.7 x (Vd/CL)

= 7/10 x 60/3

= 14

The correct answer is D



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