Studies are done on normal volunteers for phase 1 clinical trials of a new drug. The volume of distribution and clearance has been measured. The researchers now are calculating the half-life of the drug.
Assuming that the volume of distribution is 60 L and the clearance is 3 L/hour, what is the approximate half-life of this drug?
A- 1/2 an hour
B- 6 hours
C- 12 hours
D- 14 hours
E- 18 hours
Answer
To calculate the half-life of a drug, we need to memorize this equation:
t(½) = 0.7 x (Vd/CL)
= 7/10 x 60/3
= 14
The correct answer is D