Repeated USMLE Questions Step 1- Pharmacology- 275

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Q- Patients with genetic polymorphism have delay in metabolism of drugs by acetylation. Which one of the following drugs is most likely affected by that?

A- Clonidine

B- Hydralazine

C- Nitroglycerin

D- Prazosin

B- Hydralazine- It is metabolized by N-acetyltransferase (Phase II metabolism reaction) and affected by genetic polymorphism. Patients of this condition are called slow acetylator and may develop SLE-like symptoms.



Q- Which of the following is the reason that nitroglycerin is given sublingually?

A- It avoids first pass metabolism

B- It has less reflex tachycardia than other routes

C- It improves patient compliance

D- It diminishes the odds of developing methemoglobinemia

A- It avoids first pass metabolism- It increases its bioavailability and speeds its action in angina.



Q- Which one of the following medications effectively lowers intraocular pressure?

A- Atropine

B- Ergonovine

C- Morphine

D- Latanoprost

D- Latanoprost- It is prostaglandin F analogue used in glaucoma to lowers intraocular pressure.



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2 thoughts on “Repeated USMLE Questions Step 1- Pharmacology- 275”

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