Repeated USMLE Questions Step 1- Review- 11

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Q- Which one of the following medications binds tumor necrosis factor (TNF-α) and used in the treatment of rheumatoid arthritis?

A- Infliximab

B- Methotrexate

C- Paclitaxel

D- Trastuzumab

A- Infliximab- It is monoclonal antibody which binds to TNF and used also in ulcerative colitis and some other autoimmune diseases.



Q- Which one of the following conditions is characterized by painless blisters on the back of the hands and hyperpigmentation of the face?

A- Contact dermatitis

B- Dermatitis herpetiformis

C- Herpes zoster

D- Porphyria cutanea tarda

D- Porphyria cutanea tarda- it is due deficiency of uroporphyrinogen decarboxylase enzyme leading to skin fragility and facial hyperpigmentation.



Q- Which of the following pathological signs is the first visible one in atheroma formation?

A- Calcification

B- Fatty streak

C- Hemorrhage

D- Thrombus

B- Fatty steak- This is the first pathological sign seen initiating atheroma formation. It is formed on the arterial intimal surface. Other choices will be seen later in the process. Fatty streak is usually reversible.



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