A 54-year-old woman with a history of hypothyroidism, hypertension, depression and joint pains develops fatigue, facial rash, headaches, dizziness, confusion, diarrhea and personality changes. She takes levothyroxine, hydralazine, amitriptyline and ibuprofen.
Which of these drugs is most likely responsible for this patient new symptom?
A- Levothyroxine
B- Hydralazine
C- Amitriptyline
D- Ibuprofen
Answer
This patient has lupus-like symptoms. Hydralazine is one of the drugs that causing lupus-like changes. Other drugs are isoniazid, chlorpromazine, penicillamine, procainamide, interferons and quinidine.
The correct answer is B