Repeated USMLE Questions Step 1- Pharmacology- 306

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Q- A researcher is using a certain drug to experiment its effect to improve hypotension during surgical procedures. This drug is a ganglionic blocker, non-selective, non-competitive nicotinic antagonist. Which of the following drugs is the one used by this researcher?

A-Lisinopril

B-Mecamylamine

C-Methylphenidate

D-Verapamil

B-Mecamylamine-This is the only one on the list that is a ganglionic blocker. It was used on the past as anti-hypertensive drug but it is now used only on research due to its many side effects.



Q- Which of the following medications is helpful to relieve symptoms in a case of chronic heartburn?

A-Cimetidine

B-Milk of magnesium

C-Omeprazole

D-Promethazine

C-Omeprazole- This medication is an irreversible inhibitor of H/K/ATPase so, it reduces gastric acid secretion. It is used in the treatment of GERD, peptic ulcer and Zollinger-Ellison syndrome.



Q- In liver failure, which one of the following medications is used to avoid phase 1 metabolism?

A-Buprenorphine

B-Diazepam

C-Imipramine

D-Lorazepam

D-Lorazepam- This medication and oxazepam are the only benzodiazepines that undergo only phase II metabolism. Other listed drugs undergo first pass metabolism.



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