Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- A 46-year-old man underwent a kidney transplantation last week due to chronic renal failure. The surgery was successful and the transplanted kidney started to produce urine during the operation. Today, his urine examination shows high creatinine and low urinary output. He has no pain or fever. A biopsy taken from the transplanted kidney shows … Read more
Q- A 65-year-old farmer presents to your clinic complaining of shortness of breath for 6 months. Last 2 weeks he noticed that he must get up several times during the night to be able to breathe. He proudly tells you that he had never visited a doctor before although he smokes and drinks every night. … Read more
Q- A 30-year-old woman with a history of Grave’s disease presents to her physician for a routine evaluation. She was treated 2 years ago with radioactive iodine. Three months later, she was prescribed levothyroxine 0.125 mg. On her last evaluation, six months ago, her doctor lowered her dose to 0.088 mg due to decrease of … Read more
Q- A 6-year-old girl presents to the emergency room with her mother for a deep wound on her right forearm. Her mother tells you that her daughter was playing at school today and wounded herself when she fell on a big rock. When you ask her about her vaccination, she tells you that her daughter … Read more
A 2-year-old girl is presented with rectal bleeding. Her mom noticed blood in her BM yesterday and was worried about it and she decided to go to your clinic to examine her daughter. There is mild pain, not related to meals. No nausea or vomiting. The girl is healthy and her routine physical examination 2 … Read more
Q- An 18-year-old man presents to the office for evaluation of multiple swellings in his neck. On examination, he has multiple large lymph nodes in his neck. Neurological examination reveals poor coordination on walking. Biopsy of lymph node is positive for lymphoma. He is diagnosed with ataxia-telangiectasia. What is the etiology of this disorder? A- … Read more