Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 2 CK practice questions in internal medicine, surgery, obstetrics and gynecology, pediatrics, neurology and psychiatry. Each question focuses on clinical decision-making: the most likely diagnosis and the next best step in management.
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Use the Subjects menu to practice by specialty, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
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Q- A 25-year-old woman presents with a sudden-onset severe headache, photophobia, and neck stiffness. She has a fever of 38.9°C (102°F). Lumber puncture shows: Opening pressure: 280 mm H₂O WBC count: 2200/mm³ (90% neutrophils) Protein: 220 mg/dL Glucose: 30 mg/dL Which of the following is the most likely diagnosis? A- Bacterial meningitis B- Fungal meningitis … Read more
Q- A 72-year-old man with chronic obstructive pulmonary disease (COPD) presents with worsening dyspnea and cough producing purulent sputum. His O₂ saturation is 85% on room air. Which of the following is the best initial treatment? A- Oral prednisone and broad-spectrum antibiotics B- Oxygen to maintain SpO₂ between 88% and 92% C- Immediate intubation and … Read more
Q- Routine prophylactic eye antimicrobial therapy is administered to all newborns to prevent blindness caused by which of the following organisms? A- Chlamydia trachomatis B- Cytomegalovirus C- Herpes simplex virus D- Neisseria gonorrhea E- Toxoplasma gondii Q- Which of the following is the most common cause of clonic seizures in the first 24 hours … Read more
Q- A 65-year-old man presents with resting tremor, bradykinesia, and rigidity. What is the most appropriate initial treatment? A- Amantadine B- Carbidopa-levodopa C- Diazepam D- Haloperidol Q- Which of the following is the most sensitive test for diagnosing a case of acute pancreatitis? A- ALT B- Amylase C- CT of abdomen D- Lipase … Read more
Q- Which of the following is the initial treatment of choice for a case of hyperkalemia accompanied by ECG changes? A- Calcium gluconate B- Furosemide C- Insulin with glucose D- Sodium polystyrene sulfonate Q- Which of the following laboratory values is most commonly elevated in cases of obstructive jaundice? A- ALT B- AST C- … Read more
Q- which of the following is the most common infectious cause of dilated cardiomyopathy in Central and South America? A- Coxsackievirus B B- Human immunodeficiency virus (HIV) C- Rickettsia D- Trypanosoma cruzi Q- Which of the following is the most sensitive test to order in a suspected case of myocardial sarcoidosis? A- Angiography B- … Read more