Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- A 39-year-old woman presents with an inflamed ulcer on the sole of her foot not healed for 2 months. Peripheral sensations are reduced bilaterally. Elevation of which of the following laboratory tests most likely explains this condition? A- Alanine aminotransferase (ALT) B- Blood glucose C -Serum creatinine D- Urinary sodium Q- A newly born … Read more
Q- Which one of the following medications enters the cell and acts on a cytoplasmic receptor? A- Adrenaline B- Dexamethasone C- Insulin D- Propranolol Q- Which one of the following local anesthetics causes local vasoconstriction and may lead to hypertension? A- Cocaine B- Etidocaine C- Lidocaine D- Tetracaine Q- Which one of the following drugs … Read more
Q- A 60-year-old man complains of shortness of breath. Examination reveals bilateral pleural effusions and pitting edema up to the level of his thighs. Which of the following is the most likely laboratory finding in this patient? A- Anemia B- Hypoalbuminemia C- Hypoglycemia D- Neutrophilia Q- Which one of the following types of cells is … Read more
Q- Which one of the following substances is released by sympathetic postganglionic neurons that innervate renal vascular smooth muscle? A- Acetyl choline B- Dopamine C- Epinephrine D- Norepinephrine Q- Which one of the following drugs is contraindicated in a case of osteoporosis? A- Albuterol B- Calcium oxalate C- Prednisone D- Simvastatin Q- Acetazolamide and other … Read more
Q- Bronchoconstriction results from stimulation of which one of the following receptor types? A- Alpha-1- adrenergic receptors B- Beta-2- adrenergic receptors C- M2 cholinergic receptors D- M3 cholinergic receptors Q- A 72-year-old woman presents for her routine examination. She is healthy and exercising regularly. Her weight is 145 lb. and her height is 5’5. She … Read more
Q- Which one of the following medications is used in cases of schizophrenia to treat involuntary movements caused by the use of antipsychotics such as haloperidol? A- Benztropine B- Chlorpromazine C- Lamotrigine D- Sertraline Q- Which one of the following agents is a muscarinic cholinomimetic? A- Atropine B- Hexamethonium C- Pilocarpine D- Tubocurarine … Read more