Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- Which one of the following is the main mechanism of absorption of most drugs in the gastrointestinal tract (GIT)? A- Endocytosis and exocytosis B- Facilitated transport C- Passive diffusion D- Pinocytosis Q- Which one of the following agents prolongs the duration of nerve block when combined with a local anesthetic? A- Atropine B- Dobutamine … Read more
Q- Administration of which one of the following medications can lead to the development of hemolytic anemia? A- Hydralazine B- Propranolol C- Quinidine D- Verapamil Q- The effect of two medications is greater than the sum of their individual effects explains which of the following drug interactions? A- Additive B- Permissive C- Synergistic D- Tachyphylaxis … Read more
Q- In a case of methemoglobinemia, which one of the following is the most likely cause of the brown color of the patient’s blood? A- Carbon monoxide B- Decreased oxygen affinity C- Oxidized hemoglobin D- Reduced hemoglobin Q- Which of the following agents most likely causes vasoconstriction? A- Bradykinin B- Histamine C- Nitric oxide D- … Read more
Q- In which one of the following locations a mural thrombus commonly occurs following myocardial infarction? A- Left atrium B- Left ventricle C- Right atrium D- Right ventricle E- Thoracic aorta Q- Bones of calvarium and facial bones are formed by which one of the following types of ossification? A- Endochondral ossification B- Membranous ossification … Read more
Q- Which of the following anti-retroviral treatments is a non-competitive reverse transcriptase inhibitor? A- Didanosine B- Nevirapine C- Saquinavir D- Zidovudine Q- Which of the following are the most likely effects of beta blockers on the end-diastolic volume (EDV) and the ejection time (ET)? A- Both of them decrease B- Both of them increase C- … Read more
Q- Which one of the following factors is the most accurate measure for the severity of diabetic ketoacidosis? A- Blood ketones B- Serum bicarbonate level C- Serum glucose level D- Urine ketones Q- A patient develops severe diarrhea after 2 weeks of treating pneumonia with broad-spectrum antibiotics. Which of the following is the first line … Read more