Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- Which one of the following parts of the cell is the site of steroid synthesis? A- Golgi apparatus B- Peroxisome C- Rough endoplasmic reticulum D- Smooth endoplasmic reticulum Q- Which of the following errors is considered if the researcher states that there is no difference when one exists? A- Type 1 error B- Type … Read more
Q- Which of the following groups of medications prolongs GABA activity in the brain? A- Alcohols B- Barbiturates C- Benzodiazepines D- Methamphetamines B- Barbiturates- Barbiturates prolong the duration of chloride channel opening at the GABA-A receptor, thereby prolonging GABA activity. Benzodiazepines increase the frequency, Q- Which of the following medications inhibits folic acid synthesis through … Read more
Q- Which of the following differentiates Dubin-Johnson syndrome from Rotor syndrome? A- Black pigmentation of the liver B- Conjugated hyperbilirubinemia C- Level of liver enzymes D- Mode of inheritance Q- At which of these vertebral levels does the trachea bifurcate? A- Seventh cervical B- First thoracic C- Fourth thoracic D- Sixth thoracic Q- Which one … Read more
Q- Which of the following characterizes the intravenous (IV) route of administration? A- Efficacy is affected by liver disorders B- Maximum bioavailability C- Rapidly excreted D- Undergo first pass metabolism Q- Which of the following medications reduces the effectiveness of oral contraceptives? A- Carbamazepine B- Ketoconazole C- Omeprazole D- Ritonavir Q- Which of the following … Read more
Q- Prophylaxis in HIV patients with TMP-SMX should be initiated at which of the following CD4 counts? A- Under 300 B- Under 200 C- Under 100 D- Under 50 Q- Which one of the following tests is diagnostic for acromegaly? A- Fasting blood glucose level B- Serum cortisol level C- Serum growth hormone level D- … Read more
Q- Ingestion of which of the following products may cause hypertensive crisis in patients taking MAO inhibitors? A- Carbohydrates such as starch B- Gluten-rich food C- Tyramine-rich food D- Vitamin D and calcium Q- Which of the following drugs is the initial therapy for Alzheimer’s disease? A- Carbachol B- Donepezil C- Methacholine D- Pilocarpine Q- … Read more