Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- Which of the following ligaments is most likely torn in a case of posterior dislocation of the hip? A- Iliofemoral ligament B- Ischiofemoral ligament C- Sacrotuberous ligament Q- Which one of the following tests can be used to distinguish between Folic acid and vitamin B12 deficiencies? A- Serum cystathionine level B- Serum homocysteine level … Read more
Q- Which one of the following glucocorticoids can cause sodium and water retention? A- Betamethasone B- Cortisol C- Dexamethasone D- Triamcinolone Q- Which one of the following drugs acts mainly by blocking the synthesis of leukotrienes? A -Cromolyn B- Ipratropium C- Montelukast D- Zileuton Q- Which of the following controls the secretion of thyrotropin? A- … Read more
Q- Which of the following is the correct statement about the difference between a strain and a sprain? A- Strain affects ligaments, while a sprain affects muscles and tendons B- Strain affects muscles or tendons, while a sprain affects ligaments C- Strain affects muscles or ligaments, while a sprain affects tendons D- Strain affects tendons … Read more
Q- Which of the following best describes the acid-base dissociation constant (pKa) of a drug? A- The pH at which 100% of the drug becomes completely ionized B- The pH at which 100% of the drug becomes completely unionized C- The pH at which 50% of the drug is ionized and 50% unionized Q- Which … Read more
Q- Which one of the following parts of the fallopian tube is the widest and the most common site for fertilization? A- Ampulla B- Infundibulum C- Isthmus Q- Coagulation factor VIII is produced by which of the following cells? A- Endothelial cells B- Hepatic cells C- Juxtaglomerular cells D- Splenic macrophages Q- Which one of … Read more
Q- Which of the following differentiates neostigmine from pilocarpine? A- Acceleration of heart rate B- Prolonged skeletal muscle contraction C- Stimulation of bowel motility D- Stimulation of salivary glands Q- An 80 mg dose of a drug was administered to a patient. 40 mg was eliminated during the first hour. This drug follows first-order elimination … Read more