Repeated USMLE Questions Step 1 Review-171- Pharmacology

Q- A patient treated with a nonselective beta blocker develops hypoglycemia that is difficult to recognize. What explains the masking of hypoglycemia symptoms? A- Alpha receptor blockade B- Beta-1 receptor stimulation C- Beta-2 receptor blockade D- Muscarinic receptor blockade   Q- A patient with hyperlipidemia is treated with cholestyramine. What is the primary mechanism by … Read more

Repeated USMLE Questions Step 1 Review-170- Pathology

Q- A 27-year-old woman presents with a painless thyroid nodule. Biopsy shows tumor cells forming follicles but without the nuclear features of papillary carcinoma. Capsular invasion is present. What is the most likely diagnosis? A- Anaplastic thyroid carcinoma B- Follicular thyroid carcinoma C- Medullary thyroid carcinoma D- Papillary thyroid carcinoma   Q- A 50-year-old man … Read more

Repeated USMLE Questions Step 1 Review-169- Pharmacology

Q- A patient receiving trimethoprim-sulfamethoxazole develops megaloblastic anemia. Which mechanism explains this adverse effect? A- Folate metabolism inhibition B- Hemoglobin oxidation C- Inhibition of erythropoietin synthesis D- Vitamin B12 malabsorption   Q- A patient with hypertension is treated with clonidine. What is the primary mechanism by which this drug lowers blood pressure? A- Alpha-1 receptor … Read more

Repeated USMLE Questions Step 1- Review-168

Q- A 6-month-old infant presents with developmental delay, hypotonia, and a cherry-red spot on retinal examination. There is no hepatosplenomegaly. Which enzyme deficiency is most likely responsible for this condition? A- Arylsulfatase A B- β-Hexosaminidase A C- Glucocerebrosidase D- Sphingomyelinase   Q- A researcher is studying oxygen delivery in tissues. Which factor shifts the oxyhemoglobin … Read more

Repeated USMLE Questions Step 1 Review-167- Pharmacology

Q- A patient treated with vancomycin develops acute kidney injury. Which concurrent medication increases this risk most significantly? A- Amoxicillin B- Azithromycin C- Gentamicin D- Metronidazole   Q- A patient who is taking a high dose of niacin for hyperlipidemia develops hyperglycemia. What explains this effect? A- Decreased insulin secretion B- Decreased peripheral glucose uptake … Read more

Repeated USMLE Questions Step 1 Review-166- Pathology

Q- A 34-year-old woman presents with chronic diarrhea and abdominal pain. Colonoscopy reveals transmural inflammation with skip lesions. Which complication is most likely in this condition? A- Toxic megacolon B- Colorectal adenocarcinoma C- Fistula formation D- Primary sclerosing cholangitis   Q- A 58-year-old man presents with fatigue and easy bruising. Peripheral smear shows blasts with … Read more