Repeated USMLE Questions Step 1 Review-174- Pathology

Q- A 64-year-old man with a long history of smoking presents with hematuria. Cystoscopy reveals a papillary tumor arising from the bladder mucosa. Which molecular alteration is most commonly associated with low-grade papillary urothelial carcinoma? A- KRAS mutation B- FGFR3 mutation C- BRAF mutation D- APC mutation   Q- A 14-year-old boy presents with a … Read more

Repeated USMLE Questions Step 1 Review-173- Pharmacology

Q- A patient with Parkinson’s disease is treated with selegiline. What is the primary mechanism of this drug? A- Inhibition of catechol-O-methyltransferase B- Inhibition of monoamine oxidase B C- Stimulation of dopamine receptors D- Stimulation of muscarinic receptors   Q- A patient treated with verapamil develops constipation and bradycardia. What class of drug does verapamil … Read more

Repeated USMLE Questions Step 1- Review-172

Q- A child has chronic diarrhea and failure to thrive. Stool is positive for fat. The sweat chloride test is elevated. Which mechanism explains the GI symptoms? A- Decreased pancreatic enzyme secretion B- Increased bile acid synthesis C- Increased gastric acid production D- Increased intestinal chloride secretion   Q- A patient has progressive weakness and … Read more

Repeated USMLE Questions Step 1 Review-171- Pharmacology

Q- A patient treated with a nonselective beta blocker develops hypoglycemia that is difficult to recognize. What explains the masking of hypoglycemia symptoms? A- Alpha receptor blockade B- Beta-1 receptor stimulation C- Beta-2 receptor blockade D- Muscarinic receptor blockade   Q- A patient with hyperlipidemia is treated with cholestyramine. What is the primary mechanism by … Read more

Repeated USMLE Questions Step 1 Review-170- Pathology

Q- A 27-year-old woman presents with a painless thyroid nodule. Biopsy shows tumor cells forming follicles but without the nuclear features of papillary carcinoma. Capsular invasion is present. What is the most likely diagnosis? A- Anaplastic thyroid carcinoma B- Follicular thyroid carcinoma C- Medullary thyroid carcinoma D- Papillary thyroid carcinoma   Q- A 50-year-old man … Read more

Repeated USMLE Questions Step 1 Review-169- Pharmacology

Q- A patient receiving trimethoprim-sulfamethoxazole develops megaloblastic anemia. Which mechanism explains this adverse effect? A- Folate metabolism inhibition B- Hemoglobin oxidation C- Inhibition of erythropoietin synthesis D- Vitamin B12 malabsorption   Q- A patient with hypertension is treated with clonidine. What is the primary mechanism by which this drug lowers blood pressure? A- Alpha-1 receptor … Read more