Free Questions and Answers for All Medical Students all over the World
Start here: practice all 87 questions on one page in our USMLE Pharmacology Question Bank, organized by system.
Pharmacology is one of the highest-yield subjects on USMLE Step 1, and it appears in almost every system block. This page collects all of our pharmacology practice questions in one place.
High-yield pharmacology topics to master
• Mechanisms of action – know the target (receptor, enzyme or channel) for every major drug class.
• Classic side effects – ACE inhibitor cough, hydralazine lupus, amiodarone pulmonary fibrosis, aminoglycoside nephro- and ototoxicity.
• Drug interactions – CYP450 inducers (rifampin, carbamazepine) and inhibitors, warfarin interactions, digoxin and hypokalemia.
• Antidotes and toxicity – N-acetylcysteine, dantrolene, vitamin K and heparin-induced thrombocytopenia.
• Autonomic pharmacology – alpha and beta agonists and blockers, cholinergic and anticholinergic drugs.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- Prolonged use of which one of the following medications can lead to increased metabolism of warfarin? A- Meprobamate B- Phenobarbital C- Triazolam D- Zolpidem Q- Which of the following conditions is characterized by intellectual disability, self-mutilating, and gout in a young boy? A- Lesch-Nyhan syndrome B-McArdle’s disease C-Pompe disease D-Von Gierke’s disease Q- Which … Read more
Q- Long-term use of metoprolol can potentially lead to which one of the following side effects? A- Hyperglycemia B- Hypoglycemia C- Hair loss D- Increased appetite Q- Propranolol should be stopped immediately in which one of the following recently diagnosed conditions? A- Angina pectoris B- Partial AV heart block C- Supraventricular tachycardia D- Tremors Q- … Read more
Q- Which of the following medications is an effective treatment for familial Mediterranean fever? A- Acetaminophen B- Ciprofloxacin C- Colchicine D- Methotrexate Q- Which one of the following antidiabetic medications may increase the risk of bone fractures and bladder cancer? A- Acarbose B- Glyburide C- Metformin D- Pioglitazone Q- Activity of which of the following … Read more
Q- A farmer presents to the emergency room diagnosed with pesticide toxicity. Which one of the following is a cholinesterase activator? A- Edrophonium B- Isoflurophate C- Pilocarpine D- Pralidoxime Q- Which one of the following medications acts by activation of alpha-2 adrenergic receptors? A- Clonidine B- Enalapril C- Labetalol D- Phentolamine Q- Which one of … Read more
I am going to answer the sample USMLE Step 1 Questions with Explanation. These questions are available at USMLE.org A 78-year-old man comes to the office for a follow-up examination. He was discharged from the hospital 1 week ago after being treated for a nontuberculous mycobacterial infection. He started treatment with ciprofloxacin and rifampin at … Read more
Q- A 30-year-old female with a history of epilepsy is prescribed a new antiepileptic drug. The medication primarily enhances the activity of gamma-aminobutyric acid (GABA) by binding to a specific site on the GABA-A receptor, leading to increased chloride influx into neurons. Which of the following drugs is she most likely prescribed? A- Diazepam B- … Read more