Repeated USMLE Questions Step 1- Review-168

Q- A 6-month-old infant presents with developmental delay, hypotonia, and a cherry-red spot on retinal examination. There is no hepatosplenomegaly. Which enzyme deficiency is most likely responsible for this condition? A- Arylsulfatase A B- β-Hexosaminidase A C- Glucocerebrosidase D- Sphingomyelinase   Q- A researcher is studying oxygen delivery in tissues. Which factor shifts the oxyhemoglobin … Read more

Repeated USMLE Questions Step 1 Review-167- Pharmacology

Q- A patient treated with vancomycin develops acute kidney injury. Which concurrent medication increases this risk most significantly? A- Amoxicillin B- Azithromycin C- Gentamicin D- Metronidazole   Q- A patient who is taking a high dose of niacin for hyperlipidemia develops hyperglycemia. What explains this effect? A- Decreased insulin secretion B- Decreased peripheral glucose uptake … Read more

Repeated USMLE Questions Step 1 Review-166- Pathology

Q- A 34-year-old woman presents with chronic diarrhea and abdominal pain. Colonoscopy reveals transmural inflammation with skip lesions. Which complication is most likely in this condition? A- Toxic megacolon B- Colorectal adenocarcinoma C- Fistula formation D- Primary sclerosing cholangitis   Q- A 58-year-old man presents with fatigue and easy bruising. Peripheral smear shows blasts with … Read more

Repeated USMLE Questions Step 1 Review-165- Pharmacology

Q- A patient with heart failure is started on sacubitril/valsartan. What is the primary pharmacologic action of sacubitril? A- Angiotensin II receptor blockade B- Inhibition of neprilysin C- Inhibition of renin release D- Stimulation of natriuretic peptide receptors   Q- A patient taking linezolid develops thrombocytopenia after prolonged therapy. What is the underlying mechanism? A- … Read more

Repeated USMLE Questions Step 1 Review-164- Pathology

Q- A 45-year-old woman presents with episodic headaches, sweating, and palpitations. Imaging reveals an adrenal medullary tumor. Which histologic pattern is most characteristic of this tumor? A- Keratin pearls B- Psammoma bodies C- Sheets of small blue cells D- Zellballen pattern   Q- A 63-year-old man with long-standing diabetes presents with progressive renal failure. Renal … Read more

Repeated USMLE Questions Step 1 Review-163- Pharmacology

Q- A patient taking warfarin is given vitamin K. What is the primary effect of vitamin K administration? A- Decreases synthesis of clotting factors II, VII, IX, X B- Increases synthesis of clotting factors II, VII, IX, X C- Inhibits platelet aggregation D- Prevents fibrin degradation   Q- A patient taking spironolactone develops breast enlargement … Read more