Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- Thrombosis of the appendicular artery is significant due to compression by inflammatory edema. This artery arises directly from which of the following arteries? A- Inferior mesenteric artery B- Ileocolic artery C- Right colic artery D- Superior mesenteric artery Q- An autopsy of an adult shows enormous cardiomyopathy, high level of cardiac deposition of glycosphingolipids … Read more
Q- Extrapyramidal side effects develop after the use of haloperidol due to its effect on which of the following receptors? A- Alpha-adrenergic receptors B- Dopamine receptors C- Muscarinic receptors D- Nicotinic receptors Q- Which of the following is the main action of carbidopa when it is used in combination with levodopa in the management of … Read more
Q- A CT scan of the chest shows a focal, wedge-shaped area of hemorrhage in a segment of the lung. Which of the following is the most likely cause of this finding? A- Arteriosclerosis B- Atherosclerosis C- Embolism D- Thrombosis Q- Achilles tendon xanthoma is most likely characteristic of which one of the following conditions? … Read more
Q- When you suggested to a mother to vaccinate her child with MMR on a scheduled basis, she refused for religious reasons. What is the most appropriate next step? A- Explain to her with documentation the benefits and risks of immunization B- Obtain a court order C- Proceed with immunization D- Report her to the … Read more
Q- Drug-to-drug interaction based on absorption, transformation, distribution, and excretion is considered. Which one of the following types of interaction? A- Chemical interaction B- Pharmaceutical interaction C- Pharmacodynamic interaction D- Pharmacokinetic interaction Q- The effect of medications on parasympathetic function declines slowly in which one of the following organs? A- Eye B- Glands C- Heart … Read more
Q- Which one of the following anti-Parkinsonism medications should be avoided in patients with glaucoma? A- Bromocriptine B- Selegiline C- Trihexyphenidyl Q- Which one of the following intravenous anesthetics has antiemetic action? A- Fentanyl B- Ketamine C- Propofol D- Thiopental Q- Interferon alpha is indicated for the treatment of which one of the following conditions? … Read more