Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- A young boy presents with multiple skin lesions for more than a year. He is sensitive to sun and biopsies of some of his lesions show squamous cell carcinoma. Which of the following mutations is most likely present in this condition? A- Missense mutation B- Nonsense mutation C- Point mutation D- Thymidine dimers Q- … Read more
Q- Which one of the following cranial openings is located at the greater wing of sphenoid and contains the middle meningeal artery? A- Foramen lacerum B- Foramen ovale C- Foramen rotundum D- Foramen spinosum Q- Vertebral artery arises from which one of the following arteries? A- Common carotid artery B- External carotid artery C- Internal … Read more
Q- It is approved that taking daily low-dose aspirin has some benefits on avoiding risk of coronary artery disease. Which of the following is NOT an adverse effect of aspirin? A- Bleeding B- Gastritis C- Renal problems D- Tolerance Q- Which one of the following medications is a non-selective beta receptor agonist? A- Ephedrine B- … Read more
Q- A 30-year-old man tells you that when he carries a heavy lift, his muscle gives up all of a sudden. Which of the following actions is responsible for abrupt cessation of skeletal muscle contraction? A- Activation of Golgi tendon organs B- Activation of lower motor neuron C- Activation of muscle spindles D- Lower blood … Read more
Q- During development, the hypothalamus arises from which one of the following structures? A- Diencephalon B- Mesencephalon C- Metencephalon D- Telencephalon Q- Which one of the following muscles is most likely at risk due to injury of the pelvic floor during the delivery of a large-sized baby? A- Coccygeus B- Iliococcygeus C- Pubococcygeus Q- Which … Read more
Q- Which one of the following drugs is the most fatal in a drug overdose? A- Bupropion B- Citalopram C- Imipramine D- Phenelzine Q- Which of the following medications is used in opioid overdose? A-Flumazenil B- Naloxone C- Norepinephrine D- Phencyclidine Q- Amoxicillin inhibits which one of the following enzymes? A-Beta lactamase B- Squalene epoxidase … Read more