Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- A liposomal preparation of which one of the following medications may reduce the incidence of renal toxicity? A- Acyclovir B- Amphotericin B C- Ketoconazole D- Vancomycin Q- Which of the following medications is the most effective immunosuppressant in cases of organ transplantation? A- Azathioprine B- Cyclophosphamide C- Cyclosporine D- Vinblastine Q- Which of the … Read more
Q- A newborn infant presents with cleft palate and hypocalcemia. Genetic testing of the blood shows a 22q11.2 deletion. Which of the following is the most likely diagnosis? A- DiGeorge Syndrome B- Down syndrome C- Stickler syndrome D- Turner’s syndrome Q- A college student is brought to the ER for fever and agitation. Examination reveals … Read more
Q- Lidocaine is an effective antiarrhythmic because of which of the following mechanisms? A- It blocks alpha-receptors B- It block beta-receptors C- It prolongs QT interval D- It prolongs PR interval E- It suppresses excitability in ischemic areas of the heart Q- Outpatient prophylaxis of superior ventricular tachycardia (SVT) is best accomplished by which of … Read more
Q- A 12-year-old girl is brought to the emergency room with her parents. Consent from the parents is needed to proceed with the treatment. The parents speak Spanish and very little English. What is the best next step of action? A- Find any Spanish-speaking person in the clinic to interpret the instructions B- Speak to … Read more
Q- Reflex tachycardia caused by systemic albuterol can be blocked by which of the following medications? A- Dobutamine B- Metoprolol C- Phenylephrine D- Prazosin Q- Which one of the following medications can be used safely in cases of lack of liver function? A- Clonazepam B- Diazepam C- Lorazepam D- Midazolam Q- Which of the following … Read more
Q- A patient presents with painless scrotal mass and increased thyroid panel. Which of the following markers would be elevated in this patient? A- Alpha-fetoprotein B- Follicle stimulating hormone C- Human chorionic gonadotropin D- Lactate dehydrogenase Q- Niemann-Pick disease is characterized by deficiency of which one of the following enzymes? A- Alpha-glucosidase B- Arylsulfatase C- … Read more