Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q1– Patients with genetic polymorphism have a delay in the metabolism of drugs by acetylation. Which one of the following drugs is most likely affected by that? A- Clonidine B- Hydralazine C- Nitroglycerin D- Prazosin Q2– Which of the following is the reason that nitroglycerin is given sublingually? A- It avoids first pass metabolism … Read more
Q- Mitochondria are NOT found in which of the following organisms? A- Fungi B- Protozoa C- Viruses D- Yeasts Q- Measurement of the content of which one of the following could help to compare the collagen content of several tissues? A- Cysteine B- Glycine C- Hydroxyproline D- Proline Q- Which of the following explains the … Read more
Q- Which one of the following diuretics may elevate blood glucose level in some patients? A- Acetazolamide B- Hydrochlorothiazide C- Spironolactone D- Triamterene Q- Which one of the following gout treatments lowers serum uric acid? A- Allopurinol B- Colchicine C- Indomethacin D- Probenecid Q- Aminoglycosides inhibit protein synthesis through targeting which of the following? A- … Read more
Q- Which of the following is the main role of hydroxyurea in the treatment of sickle cell anemia? A- Decrease levels of HbF in red blood cells B- Decrease oxygen affinity to HbS C- Increase levels of HbF in red blood cells D- Increase ability of HbS to bind 2.3-bisphosphoglycerate Q- Which of the following … Read more
Q- A certain drug has a high serum protein binding. Which of the following is increased as a result of injecting this drug? A- Distribution of the drug B- Drug interaction C- Liver metabolism D- Renal excretion Q- Administration of spironolactone and furosemide leads to which of the following? A- Increase potassium loss B- Reduce … Read more
Q- Which of the following cell types is responsible for forming the blood brain barrier (BBB)? A- Astrocytes B- Microglia C- Oligodendrocytes D- Schwann cells Q- Which of the following esophageal disorders is the most likely a complication of HIV infection? A- Achalasia B- Adenocarcinoma C- Candida esophagitis D- Esophageal varices Q- Which of the … Read more