Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- A young man complains of daytime sleeping, cataplexy and sleep paralysis. Which of the following is the best treatment? A- Diazepam B- Hydroxyzine C- Modafinil D- Zolpidem Q- Which of the following is the most likely developmental defect associated with tetralogy of Fallot? A- Anterosuperior displacement of the infundibular septum B- Bicuspid pulmonary artery … Read more
Q- Atropine is often used prior to administration of inhalant anesthetics to reduce which of the following? A- Heart rate B- Muscle tone C- Secretions D- Vomiting Q- Which of the following is the most significant action of monoamine oxidase A? A- Metabolism of dopamine B- Metabolism of norepinephrine, serotonin and tyramine C- Metabolism of … Read more
Q- Which of the following enzymes is markedly elevated in primary biliary cholangitis? A- Alanine aminotransferase (ALT) B- Aspartate aminotransferase (AST) C- Acid phosphatase D- Alkaline phosphatase Q- Which of the following is the most likely finding on a biopsy of a case of chronic bronchitis? A- Abundant mucus with plugging of the bronchioles … Read more
Q- Which of the following adverse effects of L-DOPA is most likely the reason to limit its use? A- Depression B- Dyskinesia C- Nausea and occasional vomiting D- Orthostatic hypotension Q- Which of the following is a contraindication of the use of benzodiazepines in anxiety disorders? A- Diabetes mellitus B- Seizures C- Sleep apnea … Read more
Q- Which of the following medications acts to prevent cholesterol absorption at the small intestine brush border? A- Cholestyramine B- Colestipol C- Ezetimibe D- Gemfibrozil Q- Alcohol is oxidized in the liver by which one of the following enzymes? A-Alcohol decarboxylase B- Alcohol dehydrogenase C- Alcohol oxidase D- Alcohol reductase . Q- Which of the … Read more
Q- Which of the following statements correctly describes the relative risk of a study? A- Odds that the group with a disease was exposed to a risk factor divided by odds that the group without the disease was exposed B- Risk of developing disease in the exposed group divided by risk in the unexposed group … Read more