Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- The tracheal tube is originated from which of the following structures? A- Ductus arteriosus B- Foregut C- Fourth pharyngeal arch D- Third pharyngeal arch Q- Which of the following endocrine disorders is characterized by high blood pressure, sodium and water retention, low potassium level and decreased renin activity? A- Addison’s disease B- Pheochromocytoma C- … Read more
Q- Which one of the following neoplasms is the most likely related to HIV infection? A- Burkitt’s lymphoma B- Hodgkin’s lymphoma C- Kaposi sarcoma D- Myelocytic leukemia Q- If the prevalence of a disease is 10%, what is the chance that randomly selected 3 persons out of this population will all have the disease? A- … Read more
Q- Bioavailability of a medication is maximal when it has which of the following factors? A- High ionization B- High lipid solubility C- High plasma binding D- High water solubility B- High lipid solubility- Medications with high lipid solubility cross membranes easily and therefore have higher bioavailability, especially when given orally. High ionization, high plasma … Read more
Q- Which of the following is responsible for the wrinkled appearance of the scrotum? A- Dartos fascia B- Pampiniform plexus C- Thickened keratinized epithelium D- Tunica albuginea Q- Which of the following is a serious complication of ergotamine? A- Depression B- Headache C- Hypotension D- Prolonged vasospasm Q- Regulation of which of the following regions … Read more
Q- Dry or “sandy eyes” is seen after administration of large doses of which one of the following medications? A- Atropine B- Carbachol C- Pilocarpine D- Timolol Q- Which of the following statements correctly describes the therapeutic dose of medication? A- The amount of medication that produces the maximal rate of distribution B- The amount … Read more
Q- Which of the following is the most common cancer of the lower third of esophagus in non-alcoholic, non-smoker patients? A- Adenocarcinoma B- Melanoma C- Sarcoma D- Squamous cell carcinoma . Q- Which of the following muscles are responsible for primary abduction of the arm at the shoulder joint? A- Coracobrachialis and deltoid B- Deltoid … Read more