Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- What is the correct match regarding the genetic transmission of the following diseases? A- Duchenne muscular dystrophy- X-linked dominant B- Huntington’s disease- Autosomal recessive C- Hypophosphatemic rickets- X-linked recessive D- Leber hereditary optic neuropathy- Mitochondrial inheritance Q- Which type of hypersensitivity reaction develops from Mycobacterium tuberculosis? A- Type I B- Type II C- Type … Read more
Q- Thyroid hormone can cause which one of the following effects? A- Hypoglycemia B- Lowers blood cholesterol C- Lowers body temperature D- Lowers oxygen consumption Q- Which one of the following enzymes is associated with Lyesh-Nyhan syndrome? A- Adenosine deaminase B- Hypoxanthine-guanine phosphoribosyl transferase C- Ribonucleotide reductase D- Xanthine oxidase Q- Pemphigus is an autoimmune … Read more
Q- An old woman is having difficulty in holding or keeping her head up. She also mentions that she experiences fatigue in her hands shortly after washing dishes. Physical examination reveals neck flexion weakness as well as proximal weakness in the arms. Which of the following is the initial diagnosis for her condition? A- Meningitis … Read more
Q- Injury of which of the following nerves caused loss of sensation of the palmar surface of the lateral three and a half digits and the lateral part of the palm? A- Axillary nerve B- Median nerve C- Radial nerve D- Ulnar nerve Q- The gland responsible for the secretion of prolactin is derived from … Read more
Q- Foci of hemorrhage and necrosis in which of the following parts of the brain is characteristic of Wernicke’s encephalopathy? A- Anterior pituitary B- Basal ganglia C- Mamillary bodies D- Posterior pituitary Q- Gonadotropin-releasing hormone is produced by which of the following nuclei of hypothalamus? A-Anterior nucleus B- Arcuate nucleus C- Dorsomedial nucleus D- Ventromedial … Read more
Q- A 12-year-old female is evaluated for an enlarged phallus at puberty. Examination reveals no breast development, a blind vaginal pouch, and no uterus. Laboratory tests show normal levels of testosterone and estrogen and very low levels of dihydrotestosterone (DHT). What is the most likely diagnosis? A- Female pseudohermaphrodite B- Male pseudohermaphrodite C- True hermaphrodite … Read more