Repeated USMLE Questions Step 1- Review- 156

Q- A 6-month-old infant presents with recurrent bacterial and fungal infections. Laboratory testing shows markedly decreased CD18 expression on neutrophils. Which of the following mechanisms is primarily impaired? A- Chemotaxis toward IL-8 B- Diapedesis through endothelium C- Phagolysosome fusion D- Reactive oxygen species formation   Q- A patient with chronic alcoholism develops confusion, ophthalmoplegia, and … Read more

Repeated USMLE Questions Step 1- Review- 152

Q- A 65-year-old man with heart failure is started on spironolactone. Which adverse effect should be monitored most closely? A- Gynecomastia B- Hypocalcemia C- Hypokalemia D- Metabolic acidosis   Q- A 60-year-old man presents with weakness, fatigue, and splenomegaly. His complete blood count shows pancytopenia. Bone marrow aspiration is “dry,” but biopsy shows fibrotic marrow … Read more

Repeated USMLE Questions Step 1 Review-150- Pathology

Q- A 52-year-old man presents with chronic cough, hemoptysis, and digital clubbing. Chest X-ray reveals a coin lesion in the lung. Biopsy shows malignant glandular structures producing mucin. What is the most likely diagnosis? A- Adenocarcinoma B- Large cell carcinoma C- Small cell carcinoma D- Squamous cell carcinoma   Q- A 36-year-old woman presents with … Read more

Repeated USMLE Questions Step 1- Review- 145

Q- A patient who was involved in a motor vehicle accident 2 years ago now has chronic pain. He tells his doctor he thinks he is becoming addicted to his short-acting morphine. He has been visiting multiple physicians to obtain prescription refills. Which of the following is the most appropriate treatment for his opioid use … Read more

Repeated USMLE Questions Step 1 Review-143- Pathology

Q- A 55-year-old woman presents with multiple café-au-lait spots and soft, pedunculated skin tumors. Which genetic defect is associated with this condition? A- Deletion of chromosome 22q B- Mutation of the RB tumor suppressor gene C- Mutation of the NF1 tumor suppressor gene D- Trinucleotide repeat expansion on chromosome 4   Q- A 30-year-old woman … Read more

Repeated USMLE Questions Step 1 Review- 141- Pathology

Q- A 48-year-old man presents with jaundice, dark urine, and pale stools. Lab tests show elevated direct bilirubin and markedly elevated alkaline phosphatase. Ultrasound reveals dilation of intrahepatic bile ducts. What is the most likely cause? A-Gilbert disease B-Hemolytic anemia C-Obstruction of the common bile duct D-Viral hepatitis   Q- A 22-year-old man presents with … Read more