Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- A 34-year-old woman presents with weakness, easy fatigability and numbness and tingling of her arms and legs. CBC reveals pancytopenia and marked increase in the MCV of erythrocytes. More investigations reveal chronic atrophic gastritis. What is the most likely diagnosis? A- Aplastic anemia B- Folic acid deficiency anemia C- Iron deficiency anemia D- Vitamin … Read more
Q- A 63-year-old woman visits her physician for a follow-up after a week of antibiotic therapy for acute bronchitis. Her condition has deteriorated. Her physician suggested repeating the antibiotic. The patient disagreed, saying that she does not like to take the antibiotic, and she did not take it as prescribed. Which of the following is … Read more
Q- A 61-year-old man presents to the clinic due to dyspnea on exertion and palpitation for the last year. Last week, he started to feel chest pain when he was ascending a flight of stairs. He smokes a pack of cigarettes a day for 40 years. His vital signs are pulse 88, blood pressure 156/96 … Read more
Q- A child is brought to the emergency room after ingestion of a full bottle of medication two hours ago. The child is in a coma with tachypnea, tachycardia, and metabolic acidosis. Which of the following is the responsible medication? A- Acetaminophen B- Aspirin C- Hydrocodone D- Vitamin C Q- A 25-year-old man is brought … Read more
Q- Which one of the following parts of the lymph nodes has T lymphocytes as the predominant cell? A-Cortex B- Germinal center C- Medulla D- Paracortex Q- Which of the following layers of the heart forms the cardiac valves and continues with the intima of the aorta? A- Endocardium B- Epicardium C- Myocardium D- Pericardium … Read more
Q- Which of the following is the most dangerous adverse effect of chronic alcohol abuse? A- Cutaneous vasodilation B- Impaired judgment C- Live cirrhosis D- Respiratory depression Q- Which of the following is considered an indication of first-generation histamine H1-receptor blockers? A- Allergy B- Apoplexy C- Cough D- Peptic ulcer Q- Which of the following … Read more