Free Questions and Answers for All Medical Students all over the World
Free USMLE Step 1 practice questions covering pharmacology, pathology, biochemistry, physiology, immunology, microbiology and genetics. Many are repeated, high-yield question types that students report seeing on the real exam.
Study by subject
Use the Subjects menu to practice one topic at a time, such as pharmacology, pathology, cardiology or hematology, or work through the review sets below for mixed practice like the real exam.
Try each question before opening the answer, then read the explanation even when you get it right. Each post has 3–8 exam-style questions with answers and short explanations written by Dr. Ray Makar.
Want hundreds more? See the Repeated USMLE Questions eBook series on Amazon.
Q- Which of the following leukocytes have nuclei of 3-5 lobes and azurophilic light-pink small granules in their cytoplasm? A- Basophils B- Monocytes C- Neutrophils D- Plasma cells Q- The pericardial cavity is a space lies between which of the following structures? A- Epicardium and myocardium B- Epicardium and pericardium C- Parietal fibrous pericardium and … Read more
Q- Which of the following medications increases cardiac output in pulmonary edema following myocardial infarction? A- Dobutamine B- Lisinopril C- Metoprolol D- Verapamil Q- Which of the following screening tests should be recommended for a patient taking olanzapine for schizophrenia? A- Cancer B- Diabetes C- Hemochromatosis D- Hemolysis Q- Which one of the following anti-depressant … Read more
Q- A 30-year-old man with hypertension is prescribed labetalol. It antagonizes which of the following receptors to be effective against hypertension? A- Alpha-adrenoceptors B- Beta-adrenoceptors C- Both alpha and beta adrenoceptors D- Nicotinic receptors Q- Which of the following is the most effective role of probenecid in treating gout? A- Probenecid decreases inflammation of … Read more
Q- Which one of the following effects is correlated to direct beta1-adrenoreceptor stimulation? A- Bradycardia B- Bronchodilation C- Tachycardia D- Vasoconstriction Q- Which of the following is the most likely cause of death in cases of overdose of hypnotics? A- Cerebral edema B- Depression of the medullary respiratory center C- Hypothermia D- Status epilepticus Q- … Read more
Q- Which of the following is the most frequent and irreversible side effect of typical anti-psychotics? A- Akathisia B- Anxiety C- Dystonia D- Tardive dyskinesia Q- Which of the following is the mechanism of action of ursodiol to reduce the size of gallstones in the common bile duct? A- Dissolving calcium from the stone B- … Read more
Q- Which of the following is the effect of digoxin on a case of heart failure? A- Decreased stroke volume and vagal activity B- Increased stroke volume and cardiac output C- Increased sympathetic tone and decreased vagal activity D- Rapid conduction through AV node Q- Which of the following is the mechanism of action … Read more